diff --git a/programs/bpf_loader/src/serialization.rs b/programs/bpf_loader/src/serialization.rs
index 117c52bed8..29a6e55730 100644
--- a/programs/bpf_loader/src/serialization.rs
+++ b/programs/bpf_loader/src/serialization.rs
@@ -48,8 +48,6 @@ pub fn serialize_parameters_unaligned(
     keyed_accounts: &[KeyedAccount],
     instruction_data: &[u8],
 ) -> Result<Vec<u8>, InstructionError> {
-    assert_eq!(32, size_of::<Pubkey>());
-
     // Calculate size in order to alloc once
     let mut size = size_of::<u64>();
     for (i, keyed_account) in keyed_accounts.iter().enumerate() {
@@ -106,8 +104,6 @@ pub fn deserialize_parameters_unaligned(
     keyed_accounts: &[KeyedAccount],
     buffer: &[u8],
 ) -> Result<(), InstructionError> {
-    assert_eq!(32, size_of::<Pubkey>());
-
     let mut start = size_of::<u64>(); // number of accounts
     for (i, keyed_account) in keyed_accounts.iter().enumerate() {
         let (is_dup, _) = is_dup(&keyed_accounts[..i], keyed_account);
@@ -139,8 +135,6 @@ pub fn serialize_parameters_aligned(
     keyed_accounts: &[KeyedAccount],
     instruction_data: &[u8],
 ) -> Result<Vec<u8>, InstructionError> {
-    assert_eq!(32, size_of::<Pubkey>());
-
     // Calculate size in order to alloc once
     let mut size = size_of::<u64>();
     for (i, keyed_account) in keyed_accounts.iter().enumerate() {
@@ -209,8 +203,6 @@ pub fn deserialize_parameters_aligned(
     keyed_accounts: &[KeyedAccount],
     buffer: &[u8],
 ) -> Result<(), InstructionError> {
-    assert_eq!(32, size_of::<Pubkey>());
-
     let mut start = size_of::<u64>(); // number of accounts
     for (i, keyed_account) in keyed_accounts.iter().enumerate() {
         let (is_dup, _) = is_dup(&keyed_accounts[..i], keyed_account);