diff --git a/builder/frameworks/arduino.py b/builder/frameworks/arduino.py
index 966bd39..b08b673 100644
--- a/builder/frameworks/arduino.py
+++ b/builder/frameworks/arduino.py
@@ -24,7 +24,7 @@ http://www.stm32duino.com
 
 from os.path import isdir, join
 
-from SCons.Script import DefaultEnvironment
+from SCons.Script import COMMAND_LINE_TARGETS, DefaultEnvironment
 
 env = DefaultEnvironment()
 platform = env.PioPlatform()
@@ -92,6 +92,13 @@ if env.subst("$UPLOAD_PROTOCOL") == "dfu":
 else:
     env.Append(CPPDEFINES=[("VECT_TAB_ADDR", 0x8000000)])
 
+
+if "__debug" in COMMAND_LINE_TARGETS:
+    env.Append(CPPDEFINES=[
+        "SERIAL_USB", "GENERIC_BOOTLOADER",
+        ("CONFIG_MAPLE_MINI_NO_DISABLE_DEBUG", "1")
+    ])
+
 #
 # Lookup for specific core's libraries
 #